Fundamental LCMS

Liquid Chromatograph-Mass Spectrometry

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Chapter 1 Introduction to LCMS
Fundamentals of LC, MS and LCMS
Comparison of LCMS and other techniques
Applications of LCMS
Chapter 2 Integrating LC and MS
Basic instrumentation of LCMS
Interfaces for LCMS
Mobile phases compatible for LCMS
Chapter 4 Introduction to tandem MS systems
Core principles
Types of MS/MS systems and their key characteristics
Chapter 3 Principles of MS
Introduction to mass analyzers
Chapter 5 Challenges and development of LCMS
Analytical challenges and current limitations of LCMS
Key developments in Shimadzu's LCMS
Future trends of LCMS
Shimadzu's Comprehensive LC and MS Solutions

Fundamental Guide

 

 

Abbreviations

APCI Atmospheric Pressure Chemical Ionization
API Atmospheric Pressure Ionization
APPI Atmospheric Pressure Photoionization
CID Collision-induced Dissociation
CLAM Clinical Laboratory Automation Module
DUIS Dual Ion Source
EI Electron Ionization
ESI Electrospray Ionization
GC Gas Chromatography
GCMS Gas Chromatography Mass Spectrometry
HILIC Hydrophilic Interaction Liquid Chromatography
HPLC High-Performance Liquid Chromatography
ICP-MS Inductively Coupled Plasma Mass Spectrometry
IEC Ion Exchange Chromatography
IT Ion Trap
IT-TOF Ion Trap Time-of-Flight
LC Liquid Chromatography
LCMS Liquid Chromatography Mass Spectrometry
MALDI Matrix-Assisted Laser Desorption/Ionization
MALDI-TOF Matrix-Assisted Laser Desorption/Ionization Time-of-Flight
MRM Multiple Reaction Monitoring
MS Mass Spectrometry
MS/MS Tandem Mass Spectrometry
MW Molecular Weight
NPLC Normal Phase Liquid Chromatography
PDA Photodiode Array Detector
Q-IT Quadrupole Ion Trap
Q-TOF Quadrupole Time-of-Flight
RPLC Reversed Phase Liquid Chromatography
RT Retention Time
SEC Size Exclusion Chromatography
SIM Selected Ion Monitoring
SRM Selected Reaction Monitoring
TIC Total Ion Current
TOF Time-of-Flight
TQ Triple Quadrupole
UFMS Ultra-Fast Mass Spectrometry
UHPLC Ultra-High-Performance Liquid Chromatography
UV-VIS Ultraviolet-Visible Spectroscopy

Symbols

µ Micro
amu Atomic mass unit
B Magnetic flux density
E Electric field
e Elementary charge
g Gram
k Kilo
m Mass
m/z Mass-to-charge ratio
n Nano
Pa Pascal
V Voltage
v Velocity
z Charge
ω Oscillation frequency