Analysis of Mannitol Using RID-20A Differential Index Detector

Mannitol possesses characteristics that include low moisture absorption and low reactivity, and is therefore used as an excipient for pharmaceuticals. USP methods for D-mannitol (hereafter, "mannitol") were amended in 2014 to specify the use of refractive index detection with a 7.8 mm × 300 mm L19 column.
The RID-20A differential refractive index detector features an optical system with dual temperature control to absorb the impact of subtle changes in temperature, thereby permitting chromatograms to be generated with a stable baseline. Here, we introduce an example of mannitol analysis using the RID-20A.