Advanced i-Series

World's First Living LC

With emerging wave of innovations powered by Analytical Intelligence- ideas about what LC analysis should be, are beginning to change. Times now call for an analytical environment that can deliver identical results regardless of whether the analyst is present in the laboratory or familiar with the operating procedures, as long as the analyst performs the same operations and data analysis. The new, integrated i-Series LC system keeps the excellent performance of its predecessor but also addresses the demands of an increasingly varied range of users, locations, and approaches to analysis while always delivering highly reliable analytical results.

Developed with Our Customers in Mind

Analytical Intelligence functions simplify lab management and enable higher productivity with maximum reliability

Using new and exciting technologies to increase throughput, improve accuracy and protect valuable columns, Shimadzu is delivering what is required for continued success. Not just artificial intelligence - Analytical Intelligence. The i-Series’ Analytical Intelligence engine supports acquisition of high quality, reproducible data regardless of an operator’s skill level for both routine and demanding applications.

Advanced i-Series Features


Automation and Remote Operation/Monitoring Encourage a New Style of Work

Analytical Intelligence functions, such as FlowPilot and mobile phase monitoring, and LabSolutions™ Direct can provide an automated workflow together with remote operation and monitoring from instrument startup to analysis completion.

Automated workflows incorporate the work-style habits of experienced analysts. The result is reliable data collected over extended periods.

Using Networks for More Improvements in Work Efficiency

LabSolutions CS allows remote operation and monitoring of all instruments on the analytical network from any locations, even from home.∗ Analysis data and reports are managed on a centralized database where administrative authorization allows managers to assign appropriate operational restrictions to operators, depending on their expertise and rank.

 Must have a network in place that is appropriate for the workflow.

Mobile Phase Monitoring

Advanced Real-Time Mobile Phase Monitoring

Making sure you have sufficient mobile phase in the system—before batch analysis—is critical to keeping your lab running smoothly. If you run out of mobile phase mid-batch, you have to stop the batch and take corrective action, resulting in costly workflow delays and potential loss of samples.

To overcome this challenge, the Mobile Phase Monitor*1 enables real-time, gravimetric monitoring of mobile phase levels to ensure maximum uptime. Levels for mobile phase or autosampler rinse solution may be monitored in up to six containers*2.  A large bottle version is also available. The containers can also be checked remotely from a smart device (PC/iOS/Android).

∗1 Optional
∗2 Monitors up to 6 liquids when using 1-liter bottles, and up to 3 liquids when using large-volume bottles (2- to 5-liter bottles).

Mobile Phase Flowrate Control Function

Smart Flow Control Protects Columns

UHPLC columns can be damaged by sudden pump starts and extreme gradient changes, especially true with polymeric packings. Smart Flow Control (FlowPilot) increases the flow rate gradually to the method set point according to the status of the column oven, extending the life of your columns.

Remote Operation/Monitoring Function

Take Control of Instruments from Outside the Laboratory

Using LabSolutions Direct, analysts can operate instruments remotely and implement pre-configured methods and batch analyses using the web browser of a computer or a smart device. Instrument status and chromatograms can also be monitored remotely to reduce the time and labor required to travel to and from the laboratory for improved work efficiency.


Analytical Intelligence is not limited to automating an analytical workflow or remote operations. By aggregating and automating the knowledge and skills of experienced analysts, Analytical Intelligence enables anyone to obtain reliable data and analytical results. Analytical Intelligence is also designed for high levels of compatibility with other instruments and comes with a method migration function, thereby providing an environment where anyone is equally able to obtain data without the need for complex procedures related to data compatibility between different systems.

i-PeakFinder Automatic Peak Integration Function

Process Large Volumes of Data with High Precision in a Single Step

The manual integration of un-resolved peaks is a labor-intensive process and prone to inconsistent results depending upon the experience level of the user. Shimadzu’s proprietary i-PeakFinder peak integration algorithm is perfect for such situations. i-PeakFinder processes large volumes of data with high precision in a single step, saving a lot of time and increasing the consistency of results.

ACTO Method Migration Support Function

Considering Instrument Replacement and Method Migration

Migrating a test method (analytical conditions or method) from one instrument to another while obtaining the same chromatogram can be a challenging process. The i-Series is designed with the same internal system volumes as previous Shimadzu systems and competitor systems to ensure system compatibility and data reproducibility. An Analytical Condition Transfer and Optimization (ACTO) function also adjusts gradient start time automatically, so analysts can make adjustments to separations obtained by gradient analysis easily.

i-PDeA II Peak Deconvolution Function

Tools to Help in Dealing with Difficult Separations

The i-PDeA II peak deconvolution function uses a multivariate curve resolution alternating least squares (MCR-ALS) method to enable qualitative and quantitative analysis of peaks not fully separated by the column. The i-PDeA II can also be used to check the purity of target peaks. (Only available when using a PDA detector and LabSolutions.)


User Interface

Simple in Operation

The user interface replicates the system flow channel and is used to visually check the operating status of the system. Method editing can also be performed from the same screen. With its intuitive design, even users who are completely new to liquid chromatography can navigate the user interface with minimal training.

Maintenance Videos

Supporting the Replacement of Consumables

Reading a QR Code® shown on the touch panel directs the user to a website with instructional videos on maintenance. This feature helps improve system availability and increases efficiency.

Auto-Validation Function

Stable Operation Assured with Smart System Startup

An auto-validation function means anyone can follow a set procedure and verify the instrument condition easily. The auto-validation function examines solvent delivery stability, wavelength accuracy, absorbance accuracy, gradient accuracy, the presence of any drift/noise, and other parameters. Also, an instrument check function automatically carries out the routine inspections performed before instrument operation and creates a report showing system self-diagnostic results along with a record of consumables usage, including total solvent volume delivered by the delivery pump, total number of injections performed by the autosampler, and the number of hours the lamp has been illuminated. The system check function also manages auto-validation results, making it easy to accurately determine the operating status of the instrument.

Starting Auto-Validation

Procedures, mobile phases, and other information necessary for validation are displayed on the screen, allowing you to perform inspections by simply following the instructions.


Creating a System Check Report

Validation results can be viewed from the i-Series main unit. Validation results can also be output in a report format from a workstation.

Maximum Reliability and Stability
− Fundamental functions assure analysis results −

Open Access Sample Placement

A direct access mechanism on sample racks allows the user to place the sample on racks that are not involved in sample injection even during analysis. Furthermore, racks can be shared by multiple analysts, without interrupting the analysis of samples placed by others. Overall, this function enhances work efficiency.

System Monitoring via Smart Devices

System status and chromatograms can be viewed remotely from smart devices and home computers. Situations can be checked without needing to visit the laboratory.

Dual-Temperature Control with TC-Optics and Flow Cells

Excellent Baseline Stability

In addition to the temperature control function for flow cells, the i-Series employs new temperature control technology for detector optical systems, known as TC-Optics (Temperature Controlled Optics). This ensures a more stable baseline that is less susceptible to room temperature variation and increased precision during verification testing and quantitative testing of trace components.

Ultra-Low Carryover Performance Enables High-Sensitivity Analysis

Improved Reliability of Trace Component Analysis

Shimadzu’s proprietary flow channel design, parts, and materials reduce the carryover effects of sample residue to almost zero. Ultra-low carryover performance has been improved to 0.0025% (chlorhexidine, assigned conditions), thereby providing highly precise quantitative performance when analyzing complex samples.

For Research Use Only. Not for use in diagnostic procedures. Please contact us to check the availability of these products in your country.

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