Autonomous i-Series

High Performance Liquid Chromatograph

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Experience Sustainability In Every Separation With New Autonomous LC

i-Series | Shimadzu Asia Pacific

Five Pillars of True Autonomy

  • — Self-Diagnose & Recovery
    Pre-start diagnostics and continuous monitoring prevent faulty runs, with automatic recovery to minimize downtime.
  • — Self-Track
    Intelligent Column Management's (iCMP) universal 2D code links any column brand to its usage history, ensuring full traceability and data reliability.
  • — Self-Optimize
    AI-driven method development via LabSolutions MD ensures optimal separation and ICH Q14 compliance.
  • — Self-Integrate
    Peakintelligence automates peak detection with expert-level precision, saving ~75% analysis time.
  • — Self-Sustain
    Ecology Mode and FlowPilot cut power use and extend consumable life, reducing standby power by 95%.

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First Sustainable Autonomous LC

Eco-Driven Transformation For People And The Planet

Smart Eco Lab

Reduce

45%/95%

Power Consumption

45% power reduction in standby mode.
>95% or more power reduction after analysis completion via intelligent Auto-Shutdown

Lower

52%

Solvent Reduction

Advanced method optimization (Box-Behnken DoE) minimizes organic solvent usage by up to 52%, reducing hazardous waste disposal costs.

Lasting Lifespan

2x – 4x

Cost Of Analysis

Higher durability of parts reduces replacement frequency. That means shorter analysis interruptions during part replacements, increases the instrument uptime rate and improves operating efficiency. Rotor & Stator of HPV valve lifespan increase 4x and 2x respectively.

Smart Materials

73% made by recycled materials and 100% Bioplastic reduced packaging (-12% dimension) to minimize carbon footprint.

Column Longevity

FlowPilot Smart Ramping extends column lifespan by ~2x, reducing consumable waste.

See the i-Series in Action

The i-Series HPLC/UHPLC redefines integrated LC technology by adding innovative, intelligent and intuitive features to industry-leading performance. The system delivers outstanding data quality, improved workflow efficiency, and maximum uptime. Finally, an LC as smart and flexible as you!

Features

intelligent

The new i-Series models offer three key functionalities for diagnosis, prevention, and system restoration to maintain analytical robustness.

Diagnosis

Diagnoses Pump and Autosampler Status

During the pump's flow path check, the system identifies check valve malfunctions, while the autosampler's flow path check detects contamination and blockages in the injection system. 

Prevention

Automatic Equilibration with Column Protection

To prevent column deterioration caused by sudden pressure spikes, the mobile phase flow rate should be gradually increased as the column temperature rises. The FlowPilot flow rate control feature is synchronized with the column oven temperature, ensuring columns are protected from abrupt pressure changes during automatic equilibration.

FlowPilot

Analytical Intelligence

The pump flow rate is adjusted according to the oven temperature. As the oven reaches the specified temperature, the flow rate is gradually increased (1) and then held at half the method-specified value (2). Once the oven attains the target temperature, the flow rate is gradually raised to the full value specified in the method (3).

flowpilot

Management

iCMP Next-Generation Column Management

iCMP Next-Generation Column Management

Maintaining a record of column usage history is crucial for ensuring high data reliability. The intelligent Column Management Platform (iCMP)* provides an integrated solution for tracking column usage, improving both usability and data integrity.

* Sold separately. Only available with LabSolutions CS.

innovative

Enhancing Workflows Through Automation And Remote Monitoring

Enhancing Workflows Through Automation And Remote Monitoring

With FlowPilot automated flow rate control, mobile phase monitoring, Analytical Intelligence driven functionality, and LabSolutions Direct software, everything from system startup to analysis shutdown can be managed through automated processes or remote control/monitoring. These automated workflows embed the expertise of seasoned analysts, ensuring consistent data acquisition over extended periods while reducing manual labor in the lab and enhancing overall productivity.

intuitive

User Interface

The intuitive user interface mirrors the system's flow path, allowing users to easily visualize operating status. Methods can be created or edited directly from the same screen, streamlining operation. Designed for ease of use, the interface enables even first-time liquid chromatography users to get started with minimal training.

Auto-Validation

The auto-validation function allows any user to follow a standardized procedure to easily verify instrument condition. It automatically checks key performance metrics, such as solvent delivery stability, wavelength and absorbance accuracy, gradient precision, and signal drift or noise. In addition, a built-in instrument check function performs routine pre-run inspections and generates a comprehensive report with self-diagnostic results and consumables usage—tracking solvent volume delivered, total injections by the autosampler, and lamp operating hours. All auto-validation results are centrally managed, enabling quick and accurate assessment of instrument status.

Case Studies

➤ RIKEN Center for Sustainable Resource Science

Hydrocarbon-Free Products from Microorganisms

GCMS-QP2020 NX

Nexis GC-2030

Autonomous i-Series

Single Quadrupole GC-MS GC Systems HPLC/UHPLC/SFC Systems Biofuels and Biomass

➤ Bankyo Pharmaceutical Co., Ltd.

Prominence-i High-Performance Liquid Chromatograph

Autonomous i-Series

HPLC/UHPLC/SFC Systems Life Science Small Molecule Pharmaceutical

➤ Taiho Pharmaceutical Co., Ltd.

High Performance Liquid Chromatography: Prominence-i

Autonomous i-Series

HPLC/UHPLC/SFC Systems Life Science Small Molecule Pharmaceutical

➤ Anthem Biosciences, India

Prominence-i (i-Series)

Autonomous i-Series

HPLC/UHPLC/SFC Systems Life Science Small Molecule Pharmaceutical

Shimadzu LabTotal™ Preventive Maintenance For LC

LabTotal Flyer Page 1 LabTotal Flyer Page 2

Prevent Downtime. Protect Results. Perform with Confidence.

Unplanned downtime has no place in a modern laboratory. Like all precision instruments, LC components wear over time — and when parts exceed their recommended service interval, pressure stability and analytical accuracy can decline, often before visible failure occurs.

Our LC Preventive Maintenance Kit supports long-term system reliability through carefully selected replacement components, helping you reduce unexpected downtime, extend system lifespan, and maintain consistent, reliable results.

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Sustainability initiatives