Alsachim - A Shimadzu Group Company
In 2017, Alsachim became a part of the Shimadzu Corporation, further strengthening our comprehensive portfolio of products and solution offerings. Created in 2005, Alsachim is one of the world leaders in the synthesis of stable isotope-labelled (13C, 2H, 15N) internal standards, used in bioanalysis studies, chemicals, labelled building blocks and metabolites.
Alsachim also offers Therapeutic Drug Monitoring (TDM) devices to support hospitals and bioanalysis centres. Alsachim has, over the past 15 years, provided products to customers all over the world across various disciplines including, pharmaceutical, biotech, clinical, bio-analytical, healthcare, CROs, food, environment and research institutions.
Molecules
Alsachim is one of the world leaders in the synthesis of stable isotope-labelled (13C, 2H, 15N) internal standards, stable labelled building blocks, APIs (Active Pharmaceutical Ingredient) and metabolites used in Bioanalysis studies.
Stable isotope-labelled standards
A stable isotope-labelled (SIL) analogue is considered as the most appropriate internal standard in a quantitative bioanalytical LC-MS/MS assay. With its expertise, Alsachim offers more 6000+ of such 13C, 2H, 15N, stable isotope-labelled standards in our catalogue.
Reference standards
In instrumental analysis, reference materials are essential for analytical method qualification and calibration. Alsachim offers a range of such reference materials for pharmaceutical, doping, forensics, food and environmental analysis. Some examples include COVID-19 drugs such as remdesivir, hydroxychloroquine and favipiravir.
Building blocks
Amino acids are the building blocks of peptides and proteins. Whereas many organic functionalised molecules like aromatics, heterocycles serve as the basic components for organic synthesis. We offer a comprehensive range of such building blocks.
Metabolites
Metabolomics is an emerging science of the measurement and analysis of metabolites in cells of organisms at specific times and under specific conditions. The use of stable isotopes as internal standards is suitable for mass spectrometry-based metabolomics applications. We offer a broad range of metabolites analytical standards such as bile acids, cytochrome P450 standards, glucuronides, sulfates etc.
Therapeutic Drug Monitoring (TDM) Reagent Kits
Based on its expertise, Alsachim develops Therapeutic Drug Monitoring devices to support hospitals and bioanalysis centres in their daily work and routine operation, for drugs quantification. We propose ready-to-use reagent kits composed of calibrators, quality controls, internal standards, solvents, consumables with validated method. Our kit allows the simultaneous quantification of different drugs in complex matrix.
DOSIMMUNE™
A stable isotope-labelled (SIL) analogue is considered as the most appropriate internal standard in a quantitative bioanalytical LC-MS/MS assay. With its expertise, Alsachim offers more 6000+ of such 13C, 15N, 2H stable isotope labelled standards in our catalogue.
Therapeutic drug monitoring (TDM) of the main immunosuppressant drugs, Tacrolimus, Sirolimus, Everolimus and Cyclosporin A, is essential to allow regulating of the dosage according to drug concentration of each patients’ whole blood after organ transplantation. Recently, LC-MS/MS has been introduced in many laboratories as an alternative technology for TDM (besides Immunoassays).
Alsachim developed a reagent kit based on LC-MS/MS analytical method for the quantification of immunosuppressants drugs in whole blood: Cyclosporin A, Sirolimus, Everolimus and Tacrolimus. The DOSIMMUNE™ kit is an in vitro diagnostic device for the rapid and multiplex assay of immunosuppressants drugs for LC-MS, thanks to in-house production of stable isotope-labelled internal standards with deuterium, carbon-13. This ready-to-use kit is also for routine LC-MS/MS analysis of these immunosuppressants in whole blood sample.
DOSIMMUNE™ is available for 500 analysis (CE/IVD 227-40101-55 or RUO 227-40101-58 (Europe) / 227-40101-91 (Japan)) or 1 000 analyses (227-40100-55 CE/IVD or 227-40100-58 (Europe) / 227-40100-91 (Japan)).
DOSINACO™
Anticoagulants are commonly used to manipulate the blood coagulation process by inhibiting thrombus formation. Anticoagulants include Vitamin K antagonist, Thrombin inhibitor and Factor X inhibitor. Due to the pharmacological mode of action, the use of anticoagulants may be associated with an increased risk of potential or over bleeding from any tissue or organ which may result in post hemorrhagic anemia. A measurement of anticoagulants in plasma is essential to verify drug adherence and dose selection.
Thanks to Mass spectrometry’s specificity and sensitivity, MRM Technology and the use of in-house stable isotope-labelled internal standards, Alsachim developed DOSINACO™ kit enabling the simultaneous quantification of 9 anticoagulants in plasma (Acenocoumarol, Apixaban, Argatroban, Betrixaban, Dabigatran, Edoxaban, Fluindione, Rivaroxaban and Warfarin).
DOSINACO™ is available for 200 analysis RUO 227-40500-58 (Europe) / 227-40500-91 (Japan).
DOSIMYCO™
Therapeutic drug monitoring (TDM) of the Mycophenolic acid and its glucuronide MPA-G, is essential to allow regulating of the dosage according to the drug concentration in each patient’s plasma after organ transplantation. Recently, LC -MS/MS has been introduced in many laboratories as an alternative technology for TDM (besides Immunoassays).
Alsachim developed a reagent kit based on LC-MS/MS analytical method for the quantification of the immunosuppressant drug in plasma: Mycophenolic acid (MPA) and its glucuronide (MPA-G). The DOSIMYCO™ kit is an in vitro diagnostic device for the rapid and multiplex assay of the immunosuppressant drug for LC-MS, thanks to in-house production of stable isotope-labelled internal standards with deuterium and carbon-13. This ready-to-use kit is also for routine LC -MS/MS analysis of this immunosuppressant in plasma sample.
DOSIMYCO™ is available for 200 analysis RUO 227-40300-58 (Europe) / 227-40300-91 (Japan).
Applications
Alsachim provides products across various application and disciplines. Click below to know more about how we cater to each domain.
